Principal Research Scientist-Molecular Pharmacology

Eli Lilly and Company
October 3, 2020
Indianapolis, IN
Job Type


At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

For more than 140 years, Eli Lilly has been dedicated to meeting the health care needs of all people throughout the world. We address these needs primarily by developing innovative medicines—investing heavily in research and development. Lilly credits its exceptional employees for its success and recognizes that the key to ongoing achievement lies in attracting and retaining the best people.

The Quantitative Biology and Biophysics Department in Lilly Research Laboratories is seeking a highly experienced in vitro pharmacologist to join our team located at Lilly Corporate Center, Indianapolis, IN. Do you have expertise in mechanistic pharmacology, cell biology, biophysics and chemoproteomics? If you have experience enabling flow schemes, directing research strategy and have a solid understanding of the drug discovery process we're looking for your expertise. Our dynamic team of scientists have excelled at bringing life-saving and life-changing medicines to patients. We'd love for you to be a part of our efforts!

Some key responsibilities in this role:

  • Provide support and expertise to drug discovery programs across different therapeutic areas, from target validation to clinical candidate selection.
  • Lead project strategy and direction in collaboration with the Therapeutic Area, Chemistry and Structural Biology.
  • Determine options for hit identification approaches.
  • Investigate molecular mechanisms leading to pharmacological effect as well as the mode of action of compounds at cellular level.
  • Design workplans for target enablement as well as flow-schemes for project progression
  • Follow up clinical observations and work backward to uncover their mechanistic basis.
  • Collaborate on multidisciplinary teams, presenting scientific data in support of research projects.


Required Education and Experience:

  • Ph.D. in biochemistry, cell biology, molecular pharmacology or related subject areas, with a strong publication record.
  • 6 or more years of experience in the pharmaceutical or biotech industry beyond education or training

Additional preferred skills:

  • Strong capability to collaborate with scientist in multiple disciplines
  • Excellent oral and written communication skills
  • Strong work ethic. Scientific curiosity. Can do, will do attitude.
  • Postdoctoral experience in the area of biological sciences would be considered an advantage.
  • Knowledge of the biology of multiple target classes (enzymes, GPCRs, NHRs, transcription factors).
  • Experience/knowledge in one or more of the following therapeutic areas: Oncology, Immunology, Cardiovascular, Metabolic Diseases, and Neurosciences.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( [Click Here to Email Your Resumé] ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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